More Evidence That You Need Your Beauty Sleep!
Researchers from the Baylor College of Medicine have discovered that when the circadian clock in mice is changed, how the body responds to diet is altered.
Previous studies revealed that the circadian clock and the microbiome could significantly affect your metabolism.
“Organisms can change how their bodies process food in different ways,” Dr. Derek O’Neill, a postdoctoral fellow in obstetrics and gynecology at Baylor, said in a press release. “Here, we studied two of those strategies. One involves the circadian clock, the internal mechanism that helps orchestrate body activities such as going to sleep or when to eat. Another aspect that can affect how we metabolize our food is the microbiome, the bacteria that live in the body.”
Researchers genetically engineered the mice in the study, to lack the gene known as the Npas2 gene in the liver, which is involved in controlling circadian rhythm. Then they utilized restricted feeding, disrupting regular feeding hours, to limit the mice to food four times during the day instead of unlimited amounts of food for 12 hours at night.
The study results demonstrated that by altering the circadian clock in the liver, changes in the gut microbiome were changed. During the study, researchers fed two groups of mice the same amount of food the group that had the Nasp2 gene lost weight during the restricted feeding test. The mice that lacked the Nasp2 gene lost less weight than normal mice.
“We speculate that our findings may lead to solutions for people who are resistant to losing weight with restricted feeding as well as the opposite situation,” said Dr. Kjersti Aagaard, a professor of obstetrics and gynecology at Baylor. “This is the first scientific mechanistic study that shows clear evidence of a complex interplay between the host circadian system, the microbiome and the host metabolism when under dietary stress.”
The study was published in the American Journal of Obstetrics and Gynecology.